PLATELETS AND THROMBOPOIESIS CLEC-2 activates Syk through dimerization
نویسندگان
چکیده
1Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom; 2Centre for Molecular Medicine, Excellence Cluster Cardio-Pulmonary System, Frankfurt University Hospital, Frankfurt am Main, Germany; 3Division of Hematology, Brigham and Women’s Hospital, Department of Medicine, Harvard Medical School, Boston, MA; 4School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, United Kingdom; and 5Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
منابع مشابه
PLATELETS AND THROMBOPOIESIS Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac
The C-type lectin-like receptor 2 (CLEC-2) activates platelets through Src and Syk tyrosine kinases via a single cytoplasmic YxxL motif known as a hem immunoreceptor tyrosine-based activation motif (hemITAM). Here, we demonstrate using sucrose gradient ultracentrifugation and methyl-cyclodextrin treatment that CLEC-2 translocates to lipid rafts upon ligand engagement and that translocation is e...
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T-cell ubiquitin ligand-2 (TULA-2) is a recently discovered histidine tyrosine phosphatase thought to be ubiquitously expressed. In this work, we have investigated whether TULA-2 has a key role in platelet glycoprotein VI (GPVI) signaling. This study indicates that TULA-2 is expressed in human and murine platelets and is able to associate with Syk and dephosphorylate it. Ablation of TULA-2 resu...
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• In influenza-immune subjects, H1N1 influenza virus–containing immune complexes can activate platelets through FcgRIIA. • H1N1 can also activate platelets through thrombin, independently of FcgRIIA, pointing to a role of coagulation in influenza infection. Platelets play crucial functions in hemostasis and the prevention of bleeding. During H1N1 influenza A virus infection, platelets display a...
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1Centre for Cardiovascular Sciences, Institute of Biomedical Research, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham; and 2Rheumatology Research Group, Institute of Biomedical Research, Division of Immunity & Infection, Medical Research Council (MRC) Centre for Immune Regulation, University of Birmingham, Birmingham, U...
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Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom; Department of Experimental Biomedicine, University of Würzburg, University Hospital and Rudolf Virchow Centre, Würzburg, Germany; Max-Planck-Institute for Molecular Biomedicine, Department Vascular Cell Biology, Münster, Germany; IN...
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